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Hubungan intensitas nyeri dengan kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo

Abstract

Introduction: Breast cancer occurs because breast cells grow out of control. The incidence of breast cancer is still very high both in developed countries and in Indonesia. One treatment that can be done is chemotherapy. Pain is one of the effects that can occur in undergoing chemotherapy, besides the increasing stage of cancer can increase pain. This increased pain often affects a person's quality of life. This study aims to determine the relationship between pain intensity and quality of life of breast cancer patients undergoing chemotherapy at PPLK RSUD Dr. Soetomo.

Methods: This research is a descriptive analytical study with a cross-sectional method. Sampling was done by total sampling that met the inclusion and exclusion criteria, then filled out the Sf-36 questionnaire and the Wong Baker pain scale. Forty respondents with breast cancer underwent chemotherapy at PPLK RSUD Dr. Soetomo. Analysis using SPSS. The Shapiro Wilk test was used to determine the normality test. Correlation using Spearman's test.

Results: From 40 respondents, the youngest age in this study was 29 years old and the oldest was 61 years old. The highest level of pain in stage 4 breast cancer patients is in the mildly disturbing category, which is measured using the Wong Baker scale. The results of the Spearman test concluded that there were significant results between pain intensity and quality of life. There are 8 components in assessing the quality of life with the SF-36: physical function, physical role, emotional role, energy, mental health, social function, pain, and general health (p<0.05).

Conclusion: This study shows a relationship between pain intensity and quality of life of breast cancer patients undergoing chemotherapy.

 

 

Pendahuluan: Kanker payudara terjadi karena sel-sel payudara tumbuh di luar kendali. Angka kejadian kanker payudara masih sangat tinggi baik di negara maju maupun Indonesia. Salah satu pengobatan yang dapat dilakukan adalah kemoterapi. Nyeri merupakan salah satu efek yang dapat terjadi dalam menjalani kemoterapi, selain itu stadium kanker yang meningkat dapat meningkatkan rasa nyeri. Nyeri yang meningkat ini seringkali memengaruhi kualitas hidup seseorang. Penelitian ini bertujuan untuk mengetahui hubungan intensitas nyeri terhadap kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo.

Metode: Penelitian ini merupakan penelitian deskripsi analitik dengan metode cross-sectional. Pengambilan sampel dilakukan dengan cara total sampling yang memenuhi kriteria inklusi dan eksklusi, kemudian dilakukan pengisian kuisioner Sf-36 dan skala nyeri Wong Baker. Terdapat 40 responden penderita kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo. Analisis menggunakan SPSS. Uji Shapiro Wilk digunakan untuk menentukan uji normalitas. Korelasi hubungan menggunakan uji Spearman.

Hasil: Dari 40 responden diperoleh hasil dengan usia termuda dalam penelitian ini berumur 29 tahun dan tertua berumur 61 tahun. Tingkatan nyeri tertinggi pada pasien kanker payudara stadium 4 masuk dalam kategori agak mengganggu, yang diukur menggunakan skala Wong Baker. Hasil uji Spearman menyimpulkan adanya hasil yang signifikan antara intensitas nyeri dengan kualitas hidup. Terdapat 8 komponen dalam menilai kualitas hidup dengan SF-36, yaitu fungsi fisik, peranan fisik, peranan emosi, energi, kesehatan jiwa, fungsi sosial, rasa nyeri, dan kesehatan umum (p<0,05).

Kesimpulan: Penelitian ini menunjukkan adanya hubungan antara intensitas nyeri dan kualitas hidup pasien kanker payudara yang sedang menjalani kemoterapi.

References

  1. CDC. What Is Breast Cancer? | CDC [Internet]. 2021 [cited 2022 Jan 2]. Available from: https://www.cdc.gov/cancer/breast/basic_info/what-is-breast-cancer.htm
  2. World Health Organization (WHO). Breast cancer [Internet]. 2021 [cited 2022 Jan 2]. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer
  3. Kementerian Kesehatan Republik Indonesia. Hari Kanker Sedunia 2019 – Sehat Negeriku [Internet]. 2019 [cited 2022 Jan 2]. Available from: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20190131/2329273/hari-kanker-sedunia-2019/
  4. Melani R, Darmawan E, Raharjo B. Gambaran Hubungan Regimen Dosis Danefek Samping Kemoterapi pada Pasien Kanker di RSUD Prof Dr. Margono Soekarjo Purwokerto Periode Bulan Januari-Februari Tahun 2019. Maj Farm [Internet]. 2019;15(2):113. Available from: http://dx.doi.org/10.22146/farmaseutik.v15i2.47664
  5. Sukardja. Dasar Kemoterapi Kanker. Surabaya: Buku onkologi klinik Surabaya: Airlangga University Press; 2000.
  6. Sutandyo N. Nutrisi Pada Asien Kanker Yang Mendapat Kemoterapi. Vol. 4, Indonesian Journal of Cancer. 2007. p. 144–8.
  7. Cancer B. Treatment for IDC [Internet]. 2021 [cited 2022 Jan 2]. Available from: https://www.breastcancer.org/symptoms/types/idc/treatment
  8. Costa WA, Monteiro MN, Queiroz JF, Gonçalves AK. Pain and quality of life in breast cancer patients. Clinics (Sao Paulo) [Internet]. 2017 Dec;72(12):758–63. Available from: https://pubmed.ncbi.nlm.nih.gov/29319722
  9. Juwita DA, Almahdy A, Afdhila R. Pengaruh Karakteristik Pasien Terhadap Kualitas Hidup Terkait Kesehatan Pada Pasien Kanker Payudara di RSUP Dr.M. Djamil Padang, Indonesia. J Sains Farm Klin [Internet]. 2018;5(2):126. Available from: http://dx.doi.org/10.25077/jsfk.5.2.126-133.2018
  10. Abu Farha NH, Khatib MT, Salameh H, Zyoud SH. Cancer-related post-treatment pain and its impact on health-related quality of life in breast cancer patients: a cross sectional study in Palestine. Asia Pac Fam Med [Internet]. 2017 Nov 21;16:7. Available from: https://pubmed.ncbi.nlm.nih.gov/29200943
  11. Manoharan N, Nair O, Shukla NK, Rath GK. Descriptive Epidemiology of Female Breast Cancer in Delhi, India. Asian Pac J Cancer Prev. 2017 Apr;18(4):1015–8.
  12. Johnson RH, Anders CK, Litton JK, Ruddy KJ, Bleyer A. Breast cancer in adolescents and young adults. Pediatr Blood Cancer [Internet]. 2018/08/28. 2018 Dec;65(12):e27397–e27397. Available from: https://pubmed.ncbi.nlm.nih.gov/30156052
  13. Nurhayati. Faktor-faktor Risiko Yang Berhubungan Dengan Kejadian Kanker Payudara Di RSUD Kota Padangsidimpuan Tahun 2016. J War Ed 56. 2018;(56):1–11.
  14. Suparman E, Suparman E. Peran Estrogen Dan Progesteron Terhadap Kanker Payudara. J Biomedik [Internet]. 2014;6(3). Available from: http://dx.doi.org/10.35790/jbm.6.3.2014.6319
  15. Price, S. A. dan Wilson LM. Patofisiologi : Konsep Klinis Proses- Proses Penyakit. Jakarta: EGC; 2006.
  16. Almasi-Hashiani A, Nedjat S, Ghiasvand R, Safiri S, Nazemipour M, Mansournia N, et al. The causal effect and impact of reproductive factors on breast cancer using super learner and targeted maximum likelihood estimation: a case-control study in Fars Province, Iran. BMC Public Health [Internet]. 2021 Jun 24;21(1):1219. Available from: https://pubmed.ncbi.nlm.nih.gov/34167500
  17. Martínez ME, Unkart JT, Tao L, Kroenke CH, Schwab R, Komenaka I, et al. Prognostic significance of marital status in breast cancer survival: A population-based study. PLoS One [Internet]. 2017 May 5;12(5):e0175515–e0175515. Available from: https://pubmed.ncbi.nlm.nih.gov/28475579
  18. Olfah Y. Kanker Payudara dan SADARI. Yogyakarta: Nuha Medika. Yogyakarta: Nuha Medika.; 2013.
  19. Darmasari T. Hubungan Tingkat Pendidikan Dan Pengetahuan WUS Tentang Deteksi Dini Kanker Payudara Dengan Perilaku Pemeriksaan Payudara Sendiri Di Keluarahan Tambakrejo Kecamatan Gayamsari Kota Semarang. Skripsi Ilmu Keperawatan Fak Ilmu Keperawatan UNISSULA. 2016;
  20. Taheri M, Tavakol M, Esmaeil Akbari M, Almasi-Hashiani A, Abbasi M. Relationship of Socio Economic Status, Income, and Education with the Survival Rate of Breast Cancer: A Meta-Analysis. Iran J Public Health [Internet]. 2020; Available from: http://dx.doi.org/10.18502/ijph.v48i8.2981
  21. Leppert W, Zajaczkowska R, Wordliczek J, Dobrogowski J, Woron J, Krzakowski M. Pathophysiology and clinical characteristics of pain in most common locations in cancer patients. J Physiol Pharmacol an Off J Polish Physiol Soc. 2016 Dec;67(6):787–99.
  22. Remesh A. Toxicities of anticancer drugs and its management. Int J Basic Clin Pharmacol [Internet]. 2012;1(1):2. Available from: http://dx.doi.org/10.5455/2319-2003.ijbcp000812
  23. Hoffman M, de Pinho H, Cooper D, Sayed R, Dent DM, Gudgeon A, et al. Breast cancer incidence and determinants of cancer stage in the Western Cape. South African Med J. 2000;90(12).
  24. Firmansyah R, Khambri D, Edison E, Rofinda ZD. Kejadian Demam Neutropenia Pada Pasien Kanker Payudara Yang Mendapat Kemoterapi. Maj Kedokt Andalas. 2015;38(1):12.
  25. Cardoso F, Bedard PL, Winer EP, Pagani O, Senkus-Konefka E, Fallowfield LJ, et al. International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy. J Natl Cancer Inst. 2009 Sep;101(17):1174–81.
  26. UK CR. Vinorelbine (Navelbine)| Cancer information | Cancer Research UK [Internet]. 2019 [cited 2022 Jan 2]. Available from: https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/vinorelbine-navelbine
  27. Arora RD, Menezes RG. Vinca Alkaloid Toxicity. StatPearls [Internet]. 2021 Sep 12 [cited 2022 Jan 2]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK557842/
  28. Wu S, Zhang L, Li H, Xu J, Jiang C, Sun T. Combined use of apatinib mesylate and vinorelbine versus vinorelbine alone in recurrent or metastatic triple-negative breast cancer: Study protocol for a randomized controlled clinical trial. Trials. 2020;21(1).
  29. Ardhiansyah AO. Surgery Mapping 2: Breast Cancer. 2019.
  30. Hassan MSU, Ansari J, Spooner D, Hussain SA. Chemotherapy for breast cancer (Review). Oncol Rep. 2010 Nov;24(5):1121–31.
  31. Bennett Britton TM, Purushotham AD. Understanding breast cancer-related lymphoedema. Surgeon. 2009 Apr;7(2):120–4.
  32. Butar-Butar D, Yustina I, A.Harahap I. Idea Nursing Journal The relationship of Pain Characteristics with Anxiety of Breast Cancer Patients Undergoing Chemotherapy in dr. Pirngadi Medan Hospital. Idea Nurs J. 2015;6(3).
  33. Mittal S, Sharma A, Sharma A, Gupta K, Gaur A, Pathania V. Banded versus Single-sided bonded space maintainers: A Comparative Study. Indian J Dent Sci. 2018;10(1):29.
  34. Wahyuningsih IS. Potret Kualitas Hidup Pasien Kanker Yang Menjalani Kemoterapi. J Perawat Indones [Internet]. 2020;4(3):499. Available from: http://dx.doi.org/10.32584/jpi.v4i3.809
  35. Widyadari K, Adiputra P, Manik NG, Wetan Yuawati. Skala nyeri pada pasien kanker payudara yang dirawat di rumah sakit umum pusat sanglah pada bulan oktober 2019. J Med Udayana. 2021;10(3):99–102.
  36. Sun Y-S, Zhao Z, Yang Z-N, Xu F, Lu H-J, Zhu Z-Y, et al. Risk Factors and Preventions of Breast Cancer. Int J Biol Sci. 2017;13(11):1387–97.
  37. Mokhatri-Hesari P, Montazeri A. Health-related quality of life in breast cancer patients: review of reviews from 2008 to 2018. Health Qual Life Outcomes. 2020 Oct;18(1):338.
  38. Ware JEJ, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473–83.
  39. Skevington SM, Lotfy M, O’Connell KA. The World Health Organization’s WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group. Qual life Res an Int J Qual life Asp Treat care Rehabil. 2004 Mar;13(2):299–310.

How to Cite

Angela, D., Ardiansyah, D., & Agung Suprabawati, D. G. (2022). Hubungan intensitas nyeri dengan kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo. Intisari Sains Medis, 13(1), 109–116. https://doi.org/10.15562/ism.v13i1.1236

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