Correlation between albumin serum and frailty in geriatric inpatient and outpatient clinic at Sanglah Hospital Denpasar

Putu Shely Prihastuti Rudy; RA Tuty Kuswardhani; I Gusti Putu Suka Aryana; Nyoman Astika; Ida Bagus Putu Putrawan; Ni Ketut Rai Purnami

doi:10.15562/ism.v12i3.1137

Correlation between albumin serum and frailty in geriatric inpatient and outpatient clinic at Sanglah Hospital Denpasar

Putu Shely Prihastuti Rudy ,

RA Tuty Kuswardhani ,

I Gusti Putu Suka Aryana ,

Nyoman Astika ,

Ida Bagus Putu Putrawan ,

Ni Ketut Rai Purnami ,

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DOI: https://doi.org/10.15562/ism.v12i3.1137 |
Published: 2021-12-20

Abstract

Background. Frailty in the elderly has a bad impact on health, especially in the elderly with acute illness. Elderly with frailty has an increase susceptibility to falls, disability and death. Frailty is a common problem in elderly patients, and hypoalbuminemia suggested to increase the risk of death. This study aimed to determine the relationship between albumin and frailty.

Method: A Cross-Sectional Study was conducted from February 2018 to January 2019 at Sanglah Hospital with total 60 patients. Patients were divided into two groups, patients with hypoalbuminemia (albumin < 3.5 g/dL) and patients with normal serum albumin levels (albumin ? 3.5 g/dL). The frailty status assessment was measured with Fried's Frailty Phenotype questionnaire. Chi-square test was used to find the relationship between serum albumin and frailty.

Result: We evaluated 60 patients, 36 patients (60%) were male and 24 patients (40%) were female. The age of the study subjects ranged from 62 to 92 years. In this study 26 patients (43.3%) with hypoalbuminemia and 34 patients (56.7%) with normal serum albumin. There were 20 patients (76.9%) with frailty in the hypoalbuminemia group, compared to 11 patients (32.4%) in the group of patients with normal serum albumin. Hypoalbuminemia has a risk of 6.97 times greater frailty compared to normal albumin in elderly patients (p = 0.001).

Conclusion: This study exhibited a significant relationship between serum albumin and frailty in elderly admitted to inpatient unit and outpatient clinic. The lower the serum albumin level, the higher the probability of the elderly to experience frailty.

References

Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clinical Interventions in Aging. 2014;9:433-41.
Komisi Nasional Lanjut Usia.Profil Penduduk Lanjut Usia 2009. Jakarta: Komnas Nasional Lanjut Usia; 2010.
Pranarka, K. Penerapan Geriatrik Kedokteran Menuju Usia Lanjut yang Sehat. Univ Med. 2006;25(4):187-97.
Akirov A, Iraqi HM, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. The American Journal of Medicine. 2017;130:1465e11-1465e19.
Fried LP, Tangen C, Walston J. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56A:M146-M156.
McDermid RC, Selfox HT, Bagshaw SM. Frailty in the critically ill : a novel concept. Crit Care. 2011;15:301.
Hilmer SN, Perera V, Mitchell S, Murnion BP, Dent J, Bajorek B, et al. The assesment of frailty in older people in acute care. Australas J Ageing. 2009;28:182-8.
Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm—issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.
Masel MC, Ostir GV, Ottenbacher KJ. frailty, mortality, and health related quality of life in older mexican americans. J Am Geriatr Soc. 2010;58(11):2149–53.
Roman RO, Cathal DW, Brian AL, Rose AK. A frailty instrument for primary care : findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatrics. 2010;10(57):1471-2318.
Hubbard RE. Inflammation and frailty measures in older people. J Cell Mol Med. 2009;13:3103-9.
Schalk BW,Visser M, Penninx BW, Baadenhuijsen H, Bouter LM, Deeg DJ. Change in serum albumin and subsequent decline in functional status in older persons. Aging Clin Exp Res. 2005;17(4):297–305.
Snyder CK, Lapidus JA, Cawthon PM, Dam TL, Sakai LY, Marshall LM, et al. Serum albumin in relation to change in muscle mass, muscle strength, and muscle power in older men. J Am Geriatr Soc. 2012;60(9):1663–72.
Hong X, Yan J, Xu L, Shen S, Zeng X, Chen L. Relationship between nutrional status and frailty in hospitalized older patients. Clinical Interventions in Aging. 2018;14:105-11.
Kim J, Lee Y, Won CW, Lee KE, Chon D. Nutritional status and frailty in community-dwelling older Korean adults: the Korean frailty and aging cohort study. J Nutr Health Aging. 2018;22(7):774–8.
Corti MC, Guralnik JM, Salive ME, Sorkin JD. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA. 1994;272:1036-42.
Luk JK, Chiu PK, Tam S, Chu LW. Relationship between admission albumin levels and rehabilitation outcomes in older patients. Arch Gerontol Geriatr. 2011;53(1):84–9.
Gutiérrez JL, Rangel EI, Luna S. Impact of hypoalbuminemia on survival of frail elderly over 75 years. Med Int Méx. 2016;32(1):27-32.

[1] Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clinical Interventions in Aging. 2014;9:433-41.

[2] Komisi Nasional Lanjut Usia.Profil Penduduk Lanjut Usia 2009. Jakarta: Komnas Nasional Lanjut Usia; 2010.

[3] Pranarka, K. Penerapan Geriatrik Kedokteran Menuju Usia Lanjut yang Sehat. Univ Med. 2006;25(4):187-97.

[4] Akirov A, Iraqi HM, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. The American Journal of Medicine. 2017;130:1465e11-1465e19.

[5] Fried LP, Tangen C, Walston J. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56A:M146-M156.

[6] McDermid RC, Selfox HT, Bagshaw SM. Frailty in the critically ill : a novel concept. Crit Care. 2011;15:301.

[7] Hilmer SN, Perera V, Mitchell S, Murnion BP, Dent J, Bajorek B, et al. The assesment of frailty in older people in acute care. Australas J Ageing. 2009;28:182-8.

[8] Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm—issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.

[9] Masel MC, Ostir GV, Ottenbacher KJ. frailty, mortality, and health related quality of life in older mexican americans. J Am Geriatr Soc. 2010;58(11):2149–53.

[10] Roman RO, Cathal DW, Brian AL, Rose AK. A frailty instrument for primary care : findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatrics. 2010;10(57):1471-2318.

[11] Hubbard RE. Inflammation and frailty measures in older people. J Cell Mol Med. 2009;13:3103-9.

[12] Schalk BW,Visser M, Penninx BW, Baadenhuijsen H, Bouter LM, Deeg DJ. Change in serum albumin and subsequent decline in functional status in older persons. Aging Clin Exp Res. 2005;17(4):297–305.

[13] Snyder CK, Lapidus JA, Cawthon PM, Dam TL, Sakai LY, Marshall LM, et al. Serum albumin in relation to change in muscle mass, muscle strength, and muscle power in older men. J Am Geriatr Soc. 2012;60(9):1663–72.

[14] Hong X, Yan J, Xu L, Shen S, Zeng X, Chen L. Relationship between nutrional status and frailty in hospitalized older patients. Clinical Interventions in Aging. 2018;14:105-11.

[15] Kim J, Lee Y, Won CW, Lee KE, Chon D. Nutritional status and frailty in community-dwelling older Korean adults: the Korean frailty and aging cohort study. J Nutr Health Aging. 2018;22(7):774–8.

[16] Corti MC, Guralnik JM, Salive ME, Sorkin JD. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA. 1994;272:1036-42.

[17] Luk JK, Chiu PK, Tam S, Chu LW. Relationship between admission albumin levels and rehabilitation outcomes in older patients. Arch Gerontol Geriatr. 2011;53(1):84–9.

[18] Gutiérrez JL, Rangel EI, Luna S. Impact of hypoalbuminemia on survival of frail elderly over 75 years. Med Int Méx. 2016;32(1):27-32.

Correlation between albumin serum and frailty in geriatric inpatient and outpatient clinic at Sanglah Hospital Denpasar

Abstract

References

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