Skip to main content Skip to main navigation menu Skip to site footer

Hubungan homosistein dan Mean Platelet Volume (MPV) terhadap skor modifikasi Gensini pada pasien Coronary Artery Disease (CAD) stabil


Background: Stable Coronary Artery Disease (CAD) is one of Indonesia's most common cardiovascular diseases. One of the most influential risk factors of CAD is homocysteine and Mean Platelet Volume (MPV) levels. Research in Acute Coronary Syndrome (ACS) showed that the increase of homocysteine and MPV positively correlates with coronary artery stenosis showed by angiography. This study evaluates the relationship between MPV and homocysteine to the modified Gensini score in stable CAD.

Methods: This is a cross-sectional observational study conducted in Integrated Heart Service (IHS) Sanglah General Hospital, Bali, Indonesia. Homocysteine and MPV levels were measured and correlated with the Gensini score using the Pearson correlation test. Data were analyzed using SPSS version 20 for Windows and considered statistically significant if the p-value less than 0.05.

Results: The results showed that most of the patients were male (88.2%), non-obese (94.2%), comorbid hypertension (61.1%), taking statins (98.0%), Ejection Fraction (EF) >40% (84.3%), Glomerular Filtration Rate (GFR) > 60 ml/min/1.7 m2 (86.27%), MPV value < 9.4 (86.3%), and homocysteine levels < 15 (64.7%). There was no significant correlation between homocysteine (r = 0.071; p > 0.05) and MVP (r = 0.088; p > 0.05) on the Gensini score. Meanwhile, Pearson correlation analysis showed a significant negative correlation between serum creatinine levels and Gensini score (r = -0.383; p = 0.006) and also statistically significant in logistic regression analysis (p = 0.022).

Conclusion: The results of this study indicate that there is no significant correlation between the examination of homocysteine levels and MPV on the Gensini score in patients with stable CHD.


Latar Belakang: Penyakit Arteri Koroner (PJK) stabil merupakan salah satu penyakit kardiovaskular yang paling umum di Indonesia. Salah satu faktor risiko PJK yang paling berpengaruh adalah kadar homosistein dan Mean Platelet Volume (MPV). Penelitian pada Sindrom Koroner Akut (SKA) menunjukkan bahwa peningkatan kadar homosistein dan MPV berkorelasi positif dengan stenosis arteri koroner yang ditunjukkan oleh angiografi. Penelitian ini bertujuan untuk mengevaluasi hubungan antara MPV dan homosistein terhadap skor Gensini termodifikasi pada pasien dengan PJK stabil.

Metode: Studi observasional potong lintang dilakukan pada Pelayanan Jantung Terpadu (IHS) RSUP Sanglah, Bali, Indonesia. Kadar homosistein dan MPV diukur dan dikorelasikan dengan skor Gensini menggunakan uji korelasi Pearson. Data dianalisis menggunakan SPSS versi 20 untuk Windows dan dianggap bermakna secara statistik jika nilai p kurang dari 0,05.

Hasil: Hasil penelitian menunjukkan bahwa sebagian besar pasien berjenis kelamin laki-laki (88,2%), non-obese (94,2%), komorbid hipertensi (61,1%), mengonsumsi statin (98,0%), Ejection Fraction (EF) >40% (84,3%), Glomerular Filtration Rate (GFR) > 60 ml/min/1,7 m2 (86,27%), nilai MPV < 9,4 (86,3%), dan kadar homosistein < 15 (64,7%). Tidak ditemukan korelasi yang bermakna antara homosistein (r = 0,071; p > 0,05) dan MVP (r = 0,088; p > 0,05) terhadap skor Gensini. Sedangkan analisis korelasi Pearson menunjukkan korelasi negatif lemah bermakna antara kadar serum kreatinin dengan skor Gensini (r = -0,383; p = 0,006) dan juga bermakna secara statistik pada analisis regresi logistik (p=0,022).

Simpulan: Hasil penelitian ini menunjukkan bahwa bahwa tidak terdapat korelasi yang bermakna terhadap pemeriksaan kadar homosistein dan MPV terhadap skor Gensini pada pasien dengan PJK stabil.


  1. Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256.
  2. Handoyo V, Pertiwi GAR, Prabawa IPY, Manuaba IBAP, Bhargah A, Budiana IPG. Management of ST-elevation myocardial infarction in the setting of anterior epistaxis: focused on antiplatelet and antithrombotic therapies. Int Med Case Rep J. 2019;12:33-38.
  3. Prabawa IPY, Lestari AAW, Muliarta IM, Mardhika PE, Pertiwi GAR, Bhargah A, et al. The Stromal Cell-derived Factor-1/CXCL12 3’A-gene Polymorphism is Related to the Increased Risk of Coronary Artery Disease: A Systematic Review and Meta-analysis. Open Access Macedonian Journal of Medical Sciences. 2020;8(F):197-202.
  4. McCully KS. Homocysteine Metabolism, Atherosclerosis, and Diseases of Aging. Compr Physiol. 2015;6(1):471-505.
  5. Kang SS, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12:279-298.
  6. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8(1):148-56.
  7. Tekbas E, Kara AF, Ariturk Z, Cil H, Islamoglu Y, Elbey MA, et al. Mean platelet volume in predicting short- and long-term morbidity and mortality in patients with or without ST-segment elevation myocardial infarction. Scand J Clin Lab Invest. 2011;71(7):613-9.
  8. Kalra PR, Greenlaw N, Ferrari R, Ford I, Tardif JC, Tendera M, et al. Hemoglobin and Change in Hemoglobin Status Predict Mortality, Cardiovascular Events, and Bleeding in Stable Coronary Artery Disease. Am J Med. 2017;130(6):720-730.
  9. Jenkins PJ, Harper RW, Nestel PJ. Severity of coronary atherosclerosis related to lipoprotein concentration. Br Med J. 1978;2(6134):388-391.
  10. Bokhari SW, Bokhari ZW, Zell JA, Lee DW, Faxon DP. Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients. Coron Artery Dis. 2005;16(3):153-161.
  11. Ekici B, Erkan AF, Alhan A, Say?n I, Ayl? M, Töre HF. Is mean platelet volume associated with the angiographic severity of coronary artery disease?. Kardiol Pol. 2013;71(8):832-838.
  12. Murat SN, Duran M, Kalay N, Gunebakmaz O, Akpek M, Doger C, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology. 2013;64(2):131-6.
  13. Khamis RY, Ammari T, Mikhail GW. Gender differences in coronary heart disease. Heart. 2016;102(14):1142-1149.
  14. Kalra PR, Greenlaw N, Ferrari R, Ford I, Tardif JC, Tendera M, et al. Hemoglobin and Change in Hemoglobin Status Predict Mortality, Cardiovascular Events, and Bleeding in Stable Coronary Artery Disease. Am J Med. 2017;130(6):720-730.
  15. Chen J, Budoff MJ, Reilly MP, Yang W, Rosas SE, Rahman M, et al. Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease. JAMA Cardiol. 2017;2(6):635-643.
  16. Laddu DR, Rana JS, Murillo R, Sorel ME, Quesenberry CP Jr, Allen NB, et al. 25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Mayo Clin Proc. 2017;92(11):1660-1670.
  17. Anand IS. Pathophysiology of anemia in heart failure. Heart Fail Clin. 2010;6(3):279-288.
  18. Dogan A, Aksoy F, Icli A, Arslan A, Varol E, Uysal BA, et al. Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation. Blood Coagul Fibrinolysis. 2012;23(4):324-330.
  19. Rechci?ski T, Jasi?ska A, Fory? J, Krzemi?ska-Paku?a M, Wierzbowska-Drabik K, Plewka M, et al. Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention. Cardiol J. 2013;20(5):491-498.
  20. Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin Proc. 2008;83(11):1203-1212.
  21. Mann NJ, Li D, Sinclair AJ, Dudman NP, Guo XW, Elsworth GR, et al. The effect of diet on plasma homocysteine concentrations in healthy male subjects. Eur J Clin Nutr. 1999;53(11):895-9.
  22. Shenoy V, Mehendale V, Prabhu K, Shetty R, Rao P. Correlation of serum homocysteine levels with the severity of coronary artery disease. Indian J Clin Biochem. 2014;29(3):339-344.
  23. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175(3):433-440.
  24. Nakamura S, Ishibashi-Ueda H, Niizuma S, Yoshihara F, Horio T, Kawano Y. Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clin J Am Soc Nephrol. 2009;4(12):1892-1900.
  25. Chang, HA. Hwang, HS. Park, HK. Chun, MY. The role of mean platelet volume as a predicting factor of asymptomatic coronary artery disease. Korean J Fam Med. 2010; 31(8):600-606

How to Cite

Budiman, M. K., Sutanegara, B. A. P. D., & Lestari, A. A. W. (2021). Hubungan homosistein dan Mean Platelet Volume (MPV) terhadap skor modifikasi Gensini pada pasien Coronary Artery Disease (CAD) stabil. Intisari Sains Medis, 12(2), 437–443.




Search Panel

Made Kris Budiman
Google Scholar
ISM Journal

Bagus Ari Pradnyana Dwi Sutanegara
Google Scholar
ISM Journal

Anak Agung Wiradewi Lestari
Google Scholar
ISM Journal