Case Report

Aberrant expression of CD5 in a B-lineage Acute Lymphoblastic Leukemia (ALL): a case report

Ni Ketut Puspa Sari , Ni Nyoman Mahartini, Ni Kadek Mulyantari, Anak Agung Ayu Lydia Prawita, Ni Komang Krisnawati, I Putu Yuda Prabawa, Sianny Herawati, Made Minarti Witarini Dewi, Ekarini Katharina Yunarti Nabu

Ni Ketut Puspa Sari
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia. Email: nk.puspas@gmail.com

Ni Nyoman Mahartini
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Ni Kadek Mulyantari
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Anak Agung Ayu Lydia Prawita
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Ni Komang Krisnawati
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

I Putu Yuda Prabawa
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Sianny Herawati
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Made Minarti Witarini Dewi
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.

Ekarini Katharina Yunarti Nabu
Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia.
Online First: July 15, 2021 | Cite this Article
Sari, N., Mahartini, N., Mulyantari, N., Prawita, A., Krisnawati, N., Prabawa, I., Herawati, S., Dewi, M., Nabu, E. 2021. Aberrant expression of CD5 in a B-lineage Acute Lymphoblastic Leukemia (ALL): a case report. Intisari Sains Medis 12(2): 473-476. DOI:10.15562/ism.v12i2.1011


Background: CD5 is expressed in several B-lymphocyte malignancies, including Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), but CD5 positive B-cell lineage Acute Lymphoblastic Leukemia (ALL) is extremely rare. Aberrant T-cell antigen expression is associated with poor prognosis and is a useful marker to identify patients at increased risk. This case report aims to elaborate on the aberrant expression of CD5 in B-lineage ALL.

Case Presentation: A 16-years-old male presented with a history of gum bleeding and abdominal pain of 7 days with associated fever, weakness and bone pain of 2-month duration. The bone marrow aspiration showed lymphoblast 30 % with the positive vacuole. In addition, the immunophenotyping test indicates for leukemia B-lineage with expression CD19, CD10, HLA-DR, CD 34, and there is the aberrant expression of CD5.

Conclusion: Aberrant expression CD5 in cases of ALL B lineage is very rare. This can be associated with a poor prognosis.

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